The Uncanny is the story of Richard Storm, a producer of horror movies. He comes to England searching for the real counterpart of the ghosts that have made him rich. At a party he reads aloud the classic British ghost story which inspired his Hollywood career, and suddenly, uncannily, starts a chain of actions that literally brings to life his first horror movie.

Harper Albright is a hunter, a rider of the tide of the Uncanny, whose credo is simply, "Believe nothing." Once young and beautiful, she has devoted her life to seeking out and destroying the evil Iago, her former lover, now the hunter of their son. Harper must destroy Iago before he can find all the clues to recreate the Philosopher's Stone, which will give him immortality at the cost of his son's life.

With Richard's reading at the party, Iago's trail suddenly grows hot. A trail of ghost stories stretching from Storm's films back to the Middle Ages provide the clues which will lead to Iago.